ea0086oc5.5 | Metabolism, Obesity and Diabetes | SFEBES2022
Dearlove David
, Parry Sion
, Johnson Elspeth
, Cornfield Thomas
, Mozes Ferenc
, Dyson Pam
, Hodson Leanne
Introduction: Increased hepatic de novo lipogenesis (DNL) is often associated with greater intrahepatic triglyceride (IHTG) content and/or decreased insulin sensitivity; however, the contribution of DNL to each has not been fully elucidated. Therefore, the present work determined if increased DNL, achieved via adoption of an isocaloric high-sugar diet, resulted in concomitant increases in IHTG content and/or decreases in insulin sensitivity.Methods: Sixt...